Approximately what percentage of people with SLE experience renal manifestations?

In systemic lupus erythematosus (SLE), renal manifestations are a significant complication and a defining feature of the disease. Approximately 50% of individuals with SLE experience some form of renal involvement, which can range from mild abnormalities in urinalysis to severe nephritis. This statistic highlights the importance of monitoring kidney function in patients diagnosed with SLE, as timely identification and management of renal issues can significantly impact outcomes.

The involvement of the kidneys in SLE, often termed lupus nephritis, is a result of the autoimmune nature of the disease, where immune complexes can deposit in kidney tissues, leading to inflammation and damage. Recognizing that around half of patients may be affected emphasizes the need for healthcare providers to be vigilant in assessing for renal symptoms and urinary abnormalities in SLE patients.