Do hormonal factors play a role in the pathogenesis of SLE?

Hormonal factors, particularly estrogen, are indeed significant in the pathogenesis of Systemic Lupus Erythematosus (SLE). Epidemiological studies have shown that SLE predominantly affects women, especially during their reproductive years, suggesting a strong link between hormonal levels and the disease's development. Estrogen is thought to influence immune system activity, potentially leading to an increased susceptibility to autoimmunity.

Research has indicated that estrogen can enhance the proliferation of B cells and the production of autoantibodies, both of which are crucial in the development of SLE. Additionally, fluctuations in hormone levels, such as during menstrual cycles or pregnancy, may be associated with disease flares, further supporting the role of estrogen in the pathogenesis of SLE.

Understanding this hormonal influence is essential for developing targeted treatments and managing the disease effectively in female patients.