For a patient with SLE, what symptom typically suggests the diagnosis?

Facial rashes, particularly across the cheeks, are a hallmark symptom of systemic lupus erythematosus (SLE) and are indicative of the condition. This characteristic rash, often referred to as a "butterfly rash" or malar rash, is a key diagnostic feature of SLE and is seen in many patients with the disease. It typically appears as a red or purplish rash that spans the cheeks and bridge of the nose, and its presence can significantly aid healthcare providers in recognizing the possibility of SLE.

In contrast, severe headaches, macular degeneration, and joint pain after exercise do not specifically indicate SLE. While headaches can occur in various conditions, including lupus, they are not diagnostic on their own. Macular degeneration is unrelated to SLE, as it primarily concerns age-related vision changes. Joint pain may be experienced by individuals with SLE, but it can also arise from other causes and often is not limited to post-exercise scenarios. Therefore, the butterfly rash remains the most reliable symptom associated with SLE diagnosis.