Systemic lupus erythematosus primarily attacks which type of tissues?

Systemic lupus erythematosus (SLE) is known as a systemic autoimmune disease, meaning it has the potential to affect multiple organ systems throughout the body. However, one of its hallmark characteristics is its predominant impact on connective tissues.

Connective tissues include a wide range of structures and components that provide support and shape to the body, such as cartilage, bones, tendons, ligaments, and the vascular system. In SLE, the immune system mistakenly attacks these tissues, leading to inflammation and damage. This can manifest in various symptoms and complications, including joint pain, skin rashes, and issues with organs like the kidneys, heart, and lungs, all of which contain connective tissue.

Understanding that lymphocytes and antibodies target connective tissue helps clarify why this option is the correct answer. The impact on connective tissues is often seen in the form of arthritis, serositis (inflammation of the linings around the lungs and heart), and skin lesions, which are common in patients diagnosed with SLE. Thus, the primary target tissue in systemic lupus erythematosus is indeed connective tissue, underlying the multifaceted nature of this complex autoimmune disorder.