What is a significant role of corticosteroids in the treatment of SLE?

Corticosteroids play a significant role in the management of systemic lupus erythematosus (SLE) primarily by helping to manage inflammation and alleviate symptoms associated with the disease. SLE is characterized by an abnormal immune response that leads to widespread inflammation. Corticosteroids, such as prednisone, mimic the actions of hormones produced by the adrenal glands and are effective in reducing this inflammation, thereby mitigating pain, swelling, and other symptoms such as fatigue and skin rashes.

These medications are often used during flare-ups of the disease, and they can quickly improve the patient's condition. However, they do not cure SLE; instead, they serve as an important part of the overall treatment strategy, often in conjunction with other medications that target the underlying autoimmune response. This nuanced understanding emphasizes the necessity of corticosteroids as a tool for symptom management rather than complete disease eradication or a substitute for all other treatments.