What is the primary role of immunosuppressants in the treatment of SLE?

The primary role of immunosuppressants in the treatment of systemic lupus erythematosus (SLE) is to decrease immune system activity and manage lupus manifestations. SLE is characterized by an overactive immune system that mistakenly attacks the body's own tissues, leading to inflammation and various autoimmune symptoms. Immunosuppressants work by inhibiting specific components of the immune system, thereby reducing the autoimmune response that contributes to disease symptoms, such as joint pain, skin rashes, and organ damage.

By dampening the immune response, these medications help control flares of the disease and prevent complications that can arise from unchecked inflammation. This strategy is crucial because managing the symptoms effectively improves the patient's quality of life and lowers the risk of severe organ involvement, which is a significant concern in SLE.