Which class of medications might be used to treat severe manifestations of systemic lupus erythematosus (SLE)?

Immunosuppressive agents are significant in the treatment of severe manifestations of systemic lupus erythematosus (SLE) because they help to reduce the overactive immune response that characterizes the disease. SLE is an autoimmune disorder where the immune system mistakenly attacks the body’s own tissues, leading to inflammation and damage in various organs such as the kidneys, skin, and joints.

The use of immunosuppressive agents, such as corticosteroids, azathioprine, and mycophenolate mofetil, helps to lower the activity of the immune system, thereby alleviating inflammation and preventing further damage. This is critical in managing severe lupus symptoms, particularly when organs are involved.

While antibiotics are important for managing infections, they do not address the underlying autoimmune process of SLE. Antidepressants may be prescribed for mood disturbances in SLE patients but are not effective for treating the disease itself. NSAIDs (nonsteroidal anti-inflammatory drugs) can be used for symptomatic relief of mild to moderate pain and inflammation, but they may not be sufficient for severe cases where a stronger immunosuppressive treatment is necessary. Thus, the role of immunosuppressive agents in modulating the immune response is essential for effectively managing