Which demographic group is most commonly affected by systemic lupus erythematosus?

Systemic lupus erythematosus (SLE) predominantly affects women, particularly those of childbearing age, which is typically defined as between 15 to 44 years old. This demographic is particularly at risk due to hormonal influences, specifically the role of estrogen, which may contribute to the development of autoimmune conditions like lupus.

The disease often manifests during this time in life, highlighting the significance of this age group in the epidemiology of SLE. Although men and other demographics can certainly develop lupus, the prevalence and incidence rates are significantly higher among women of childbearing age, making this group the most commonly affected.

Consideration of other demographic groups reveals that systemic lupus erythematosus is less common in men and is not typically linked to childhood or older age. While older adults can develop lupus, the striking pattern of occurrences among younger women remains a defining characteristic of the disease.