Which demographic is more frequently diagnosed with systemic lupus erythematosus?

Systemic lupus erythematosus (SLE) is primarily diagnosed in women of childbearing age, typically between the ages of 15 and 45. This demographic is at a heightened risk due to hormonal factors, particularly estrogen, which may play a role in the disease's pathogenesis. The higher prevalence in this group can also be linked to genetic predispositions and environmental factors that affect young women differently compared to other demographic groups.

In contrast, older males, young children, and individuals over 60 years old tend to have a lower incidence of SLE. While lupus can occur in these groups, it is significantly less common, especially among older males who generally have a much lower risk. The disease can manifest at any age but shows a distinct peak among women during their reproductive years, making this demographic the most frequently diagnosed.