Which demographic is most commonly affected by SLE?

Systemic Lupus Erythematosus (SLE) primarily affects women, especially those of childbearing age, which is typically defined as ages 15 to 45. This demographic is particularly susceptible due to a combination of genetic, hormonal, and environmental factors that contribute to the development of the disease. Estrogen, which plays a significant role in women's reproductive health, is thought to influence the immune system in ways that can predispose women to autoimmune conditions like SLE.

Because SLE is less common in men and tends to arise earlier in life for women, other demographics such as children under 12 and older adults do not reflect the typical age and gender distribution of this disease. The presence of SLE is significantly lower in these groups. Therefore, it is accurate to assert that women of childbearing age represent the majority of individuals diagnosed with SLE.