Which factor can increase the risk of exacerbating systemic lupus erythematosus (SLE)?

Pregnancy can significantly increase the risk of exacerbating systemic lupus erythematosus (SLE) due to the complex interplay of hormonal and immunological changes that occur during this time. During pregnancy, the body undergoes alterations in the immune system to accommodate the developing fetus, which can lead to increased disease activity in women with SLE. Hormonal changes, particularly related to estrogen levels, can also trigger or worsen SLE symptoms.

Furthermore, pregnant individuals with SLE are at greater risk for developing complications such as lupus flares, preeclampsia, and other associated risks, thereby necessitating careful monitoring and management throughout the pregnancy. The disease's activity can fluctuate during this period, highlighting the importance of managing SLE proactively in these patients.

Fever, gastrointestinal upset, and hypotension, while they can be symptoms associated with various conditions, are not known to specifically provoke exacerbations of SLE in the same way that pregnancy does.