Which medication class is primarily used to manage inflammation in SLE?

Corticosteroids are primarily used in the management of inflammation associated with systemic lupus erythematosus (SLE). They are effective in reducing the immune system's overactivity, which plays a significant role in the inflammatory processes characteristic of SLE. By modulating the immune response, corticosteroids help to alleviate symptoms and prevent flares, making them a cornerstone in the treatment regimen for patients experiencing severe inflammation, particularly during active disease phases.

Other classes of medications, like antibiotics, are aimed at treating infections, not inflammation. Antidepressants target mood disorders and do not directly address the inflammatory aspects of SLE. Antihistamines are primarily used for allergic reactions and are not effective in managing the underlying inflammation in autoimmune diseases like lupus. Thus, corticosteroids are the appropriate choice when focusing specifically on inflammation management in SLE.