Which organ systems can be affected by SLE?

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that can impact multiple organ systems throughout the body. The condition is characterized by the production of autoantibodies that can target various tissues, resulting in inflammation and damage.

The correct answer highlights the fact that SLE is not limited to a single organ system but can affect the skin, joints, kidneys, heart, and other organs. For instance, skin manifestations such as a butterfly rash are common, while joint pain and inflammation (arthritis) often occur. Renal involvement is a critical aspect of SLE, as lupus nephritis can lead to severe kidney damage. Additionally, cardiovascular risks associated with SLE include increased chances of pericarditis and other heart-related issues.

In contrast, the other options suggest a limited scope of organ involvement. They incorrectly imply that SLE affects only one specific system, which fails to capture the systemic nature of the disease. The multi-organ impact of SLE is a key characteristic and understanding this breadth is crucial for proper diagnosis, management, and treatment of the disease.