Which symptom is often reported during an exacerbation of systemic lupus erythematosus?

During an exacerbation of systemic lupus erythematosus (SLE), joint swelling and pain are commonly reported symptoms. This occurs due to inflammation caused by the autoimmune response in SLE, where the body's immune system mistakenly attacks its own tissues. The inflammatory process affects the joints, leading to discomfort, swelling, and stiffness, particularly in the hands, wrists, and knees.

While other symptoms like constant fever might sometimes be present, they are not as directly associated with joint involvement as swelling and pain. Increased appetite is generally not linked to SLE exacerbations; in fact, individuals may experience the opposite due to illness. Highly elevated blood pressure is not a typical symptom of SLE exacerbation but can occur in related complications rather than as a primary response to the disease flare. Joint issues like swelling and pain are hallmark features that reflect the disease process in SLE, making them a significant symptom during exacerbations.